Table 1.
Cytotoxicity (EC50) of oxathiine fused 1,4-naphthoquinone tetracycles on cancer and non-cancer cell lines (μM).
| Compound | Tested Cell Lines | |||
|---|---|---|---|---|
| Neuro 2a * | HeLa * | Ascites Ehrlich Carcinoma ** | Jb6 Cl 41-5a * | |
| 17a | >25 | >25 | >25 | >25 |
| 17b | - *** | - | - | - |
| 17c | >25 | >25 | >25 | >25 |
| 17d | >25 | >25 | >25 | >25 |
| 18a | 2.4 | 10.9 | 8.8 | 1.5 |
| 18b | 2.9 | 8 | 1.1 | 2.9 |
| 18c | 4.1 | 10.1 | 4.5 | 3.8 |
| 18d | 2.8 | 8.7 | 4.1 | 4.3 |
| 19a | 4.1 | 3.7 | 0.6 | 5.6 |
| 19b | 2.3 | 2.7 | 0.7 | 0.9 |
| 19c | 13.3 | 4.9 | 7.4 | 5.9 |
| 19d | 2.2 | 1.3 | 1.1 | 2.3 |
| 20a | 0.7 | 6.3 | 2.7 | 0.7 |
| 20b | 1.2 | 4.7 | 1.1 | 0.5 |
| 20c | 2.2 | 2.3 | 0.7 | 0.3 |
| 20d | 1.4 | 0.4 | 1.2 | 0.7 |
| Juglone | >100 | >100 | >100 | >100 |
| Cucumarioside A2-2 | 37.5 | 42.4 | 18.5 | 15.1 |
* Cytotoxicity evaluation with MTT reagent; ** cytotoxicity evaluation with with FDA; *** non-tested due to poor solubility.