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. 2020 Aug 8;9(8):1859. doi: 10.3390/cells9081859

Figure 5.

Figure 5

BC200 RNA promotes TMZ resistance in GB through sponge miR-218-5p. (A) The viability of shBC200 and OEBC200 GB cell lines was analyzed through SRB assay 48 h after TMZ (0–1000 μM) treatment. (B) The levels of MGMT, BCRP1, MDR1, and MRP1 following shBC200 and OEBC200 in GB cells were determined through western blot. (C) MicroRNA profiling analyses showed that shBC200 and OEBC200 contained high and low levels of miR-218-5p, respectively. (D) LncBase Predicted v.2 predicted that a high binding score of miR-218-5p with BC200. (E) BC200 directly interacts with multiple binding sites to hsa-miR-218-5p. *** p < 0.001.