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. 2020 Jul 24;9(8):2364. doi: 10.3390/jcm9082364

Table 1.

Basic demographic, clinical, and laboratory characteristics of 304 pregnant women before antibiotic treatment of erythema migrans in comparison with 304 sex- and age-matched patients diagnosed with erythema migrans in the same year.

Pregnant Women Control Group p Adjusted p
No. of patients 304 304
Age (years) 29.5 (27–33) 29 (26–33)
Tick bite a 191 (62.8; 57.1–68.3) 190 (62.5; 56.8–68.0) >0.99 >0.99
Interval from bite to EM onset (days) b 14 (7–24) 13 (8–21) 0.92 >0.99
Interval from EM onset to diagnosis and treatment (days) 7 (4–18) 8 (4–22) 0.10 0.55
Location of EM c: 0.009 0.062
Extremities 256 (84.2; 79.6–88.1) 227 (74.7; 69.4–79.5)
Trunk 43 (14.1; 10.4–18.6) 73 (24.0; 19.3–29.2)
Head, neck 5 (1.6; 0.5–3.8) 4 (1.3; 0.4–3.3)
Size of EM c (cm) 10 (7–16) 10 (7–17) 0.54 >0.99
Ring-like appearance of EM c: 129 (42.4; 36.8–48.2) 168 (55.3; 49.5–60.9) 0.002 0.016
Local symptoms 170 (55.9; 50.1–61.6) 182 (59.9; 54.1–65.4) 0.37 0.97
Itching d 154 (50.7; 44.9–56.4) 163 (53.5; 47.8–59.3)
Burning d 26 (8.6; 5.7–12.3) 33 (10.9; 5.6–14.9)
Pain d 26 (8.6; 5.7–12.3) 39 (12.8; 9.3–17.1)
Constitutional symptoms 68 (22.1; 17.8–27.5) 113 (37.2; 31.7–42.9) <0.001 0.002
Fatigue d 29 (9.5; 6.5–13.4) 62 (20.4; 16.0–25.4)
Headache d 33 (10.9; 7.6–14.9) 62 (20.4; 16.0–25.4)
Myalgias d 12 (4.0; 2.1–6.8) 24 (7.9; 5.1–11.5)
Arthralgias d 18 (5.9; 3.5–9.2) 32 (10.5; 7.3–14.5)
Fever d 5 (1.6; 0.5–3.8) 8 (2.6; 1.1–5.1)
Dizziness d 7 (2.3; 0.9–4.7) 11 (3.6; 1.8–6.4)
Multiple EM 14 (4.6; 2.5–7.6) * 16 (5.3; 3.0-8.4) ** 0.71 >0.99
Other manifestations of LB e 2 0

Data are medians (interquartile range) or frequencies (percentage; 95% confidence interval). p values were obtained with Mann–Whitney tests for numeric variables and chi-squared Fisher’s exact tests for categorical variables. Abbreviations: EM, erythema migrans; LB, Lyme borreliosis. a At site of later EM skin lesion; b data for 189/191 pregnant and 185/190 non-pregnant women who recalled a tick bite at the site of later EM; c findings for the primary lesion in patients with multiple EM; d number (%) of patients reporting an individual symptom; e one patient with associated borrelial lymphocytoma, one with transitory cardiac conduction disorder; * number of skin lesions: 2–13 (IQR 2–6); ** number of skin lesions: 2–12 (IQR 2–3).