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. 2020 Aug 4;12(8):2161. doi: 10.3390/cancers12082161

Figure 2.

Figure 2

OAT-449 inhibits tumor growth in HT-29 and SK-N-MC xenografts into BALB/c Nude mice. (a) Mean tumor volume of HT-29 cell xenografts, measured every 3 days during drug administration. OAT-449 and vehicle solutol (5 following days, 2 day intervals), CPT-11 (40 mg/kg q3d) were administered IP. The number of animals in each group was 11. (b) Mean tumor volume in mice xenografted with SK-N-MC cells during drug administration. Tumor size was measured every 3 days. OAT-449 was administered intravenously at a dose of 2.5 mg/mL, as well as vincristine (1 mg/kg every 7 days) and diluent (solutol, every 5 days). N = 8 for vehicle and vincristine group and n = 4 for OAT-449 group. **** p < 0.0001.