Figure 6.

Violin plots showing the drug-induced LQTS risk score factor broken down by sex at baseline and after the virtual addition of repurposed drugs into PACE participants’ drug regimens. Fexofenadine and terfenadine (alone and combined with AZ) were used as negative and positive controls, respectively, on drug-induced LQTS scores. The white dots are the medians, and the colored areas are probability density estimates. Male and female are represented by blue and pink colors, respectively. p < 0.05 female vs. male for the baseline and for all repurposed drugs and controls. Size of effect, p < 0.0001 for all added drugs vs. the baseline, except for fexofenadine. Abbreviations: HCQ, hydroxychloroquine; AZ, azithromycin; CQ, chloroquine; LPV/r, lopinavir + ritonavir; m, male; and f, female.