Figure 1.

Structural regions analyzed in this study. The structural regions were defined based on solvent-accessible surface areas measured from protein complex structures. Residues with changes in relative solvent accessible surface area (rASA; see Methods) between the bound and unbound conformations were defined as core residues (red) if rASAs are smaller than 0.25 and rim residues (blue) if rASAs are greater than 0.25 in the bound structures. Buried residues are non-interface residues with rASAs smaller than 0.25 in the unbound structures, and the remainder are surface residues (gray). Because the full-length protein often contains regions without structural data coverage, these structurally undefined sequences were classified as external regions in our analyses.