Table 4.

Pharmacokinetics of Tenalisib.

Parameter	200 mg BID		400 mg BID		800 mg BID		800 mg BID (fed)
	C1D1	C2D1	C1D1	C2D1	C1D1	C2D1	C1D1	C2D1
Cmax * (ng/mL)	1297.3	1651.4	2196.7	2897.7	3995.7	3231.5	2668.0	4165.6
AUC0–∞ * (h * ng/mL)	3538.3	4018.0	6530.9	5603.9	17,363.7	17,159.4	14,538.5	14,233.8
AUC(0-τ) * (h * ng/mL)	3503.0	3970.8	6415.5	5526.8	16,424.2	16,200.3	13,591.2	13,555.3
Tmax # (h)	1.0	0.5	0.8	0.5	1.1	2.1	2.1	1.1
t1/2 * (h)	1.6	1.8	1.9	2.0	2.6	2.6	2.6	2.8
λz (h−1)	0.4	0.4	0.4	0.4	0.3	0.3	0.3	0.3

C_max = Maximum plasma concentration; AUC_0-∞ = Area under the curve to infinity; AUC_(0-τ) = Area under the plasma concentration-time curve from time of administration to the end of the dosing interval; T_max = Time taken to reach maximum concentration; t_1/2 = Elimination half-life. λ_z = Apparent terminal elimination rate constant; BID = Twice a day; C = Cycle; D = Day. * Geometric mean; # Median.