Table 1.

Hereditary syndromes resulting in osteosarcoma development.

Syndrome	% of OS	Genes Mutated	References
Li–Fraumeni syndrome	12%	TP53	[20,28]
Retinoblastoma syndrome	7%	RB	[49]
Rothmund–Thomson type II (RTS II) syndrome	32%	RECQL4	[28]
RAPALIDINO syndromes	13.3%	RECQL4	[20]
Werner syndrome		WRN
Bloom syndrome		BLM
Diamond–Blackfan anemia	5.4% 0.9%	RPS19, RPL5, RPL11, RPL35A, RPS24, RPS17, RPS7, RPS10, RPS26	[47] [48]