Table 2.

Comparison of altered genes in pediatric and adolescent/adult patients in osteosarcoma based on [4,87].

Process	Pediatric	Adolescent/Adult
Control of cell cycle and apoptosis	TP53, RB1, CDKN2A, CDK4, MDM2, MYC, CARD11, CTNND1, BLM, CCNE1, COPS3, PRKCA	TP53,
PI3K-mTOR and RAS-signaling pathways	EGFR, GNAQ, GNAS, ALK, PDGFRA, PDGFRB, PIK3CA, AKT2, PIK3R1, PTEN, TSC2, VHL, CBL	PIK3CA,
Notch-signaling pathway	NOTCH1-4, MAML2, FBXW7, PDPK1, AKT1, E1F4B	AKT1,
DNA damage repair	BRCA1, BRCA2, MLH1, BAP1, ATM, WRN	SETD2, FBXW7
Chromatin modification	ATRX, FANCE, RECQL4, ARID1A, EP300	H3F3A
Regulation of transcription	Runx1, GAS7, MLLT3
Angiogenesis		TIE1 and KDR