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. 2020 Jul 31;12(8):2130. doi: 10.3390/cancers12082130

Table 3.

Driver (strong inductors) and synergistic genes (need “a cooperation” with driver genes) in which alterations may lead to osteosarcoma [89,90,92,93].

Driver Genes Synergistic Genes
TP53, NOTCH1, MYC, FOS, NF2, WIF1, BRCA2, APC, PTCH1, PRKAR1A RB1, TWIST, PTEN, JUN