Table 2.
Hematologic and non-hematologic toxicity profiles.
| Toxicities | Treatment Emergent Adverse Events (Total = 196 Cycles, %) | Grade 1–2 | Grade 3–4 | ||
|---|---|---|---|---|---|
| No. | % | No. | % | ||
| Hematological | |||||
| Neutropenia | 70 (35.7) | 2 | 1.0 | 68 | 34.7 |
| Anemia | 49 (25.0) | 43 | 21.9 | 6 | 3.1 |
| Thrombocytopenia | 22 (11.2) | 14 | 7.1 | 8 | 4.1 |
| Infectious | |||||
| Febrile neutropenia | 8 (4.1) | 0 | 0 | 8 | 4.1 |
| Other infection | 3 (1.5) | 2 | 1.0 | 1 | 0.5 |
| Gastrointestinal | |||||
| Mucositis | 28 (14.3) | 26 | 13.3 | 2 | 1.0 |
| Nausea/vomiting | 15 (7.7) | 14 | 7.1 | 1 | 0.5 |
| Constipation | 7 (3.6) | 6 | 3.1 | 1 | 0.5 |
| Neurological | |||||
| Sensory | 66 (33.7) | 64 | 32.7 | 2 | 1.0 |
| Motor | 10 (5.1) | 8 | 4.1 | 2 | 1.0 |
| Central nervous system | 1 (0.5) | 0 | 0 | 1 | 0.5 |
| Cutaneous | 9 (4.6) | 9 | 4.6 | 0 | 0 |
| Musculoskeletal | 14 (7.1) | 14 | 7.1 | 0 | 0 |