Table 1.
Baseline characteristics of the study cohort.
| Group A (n = 22) Patients with ARDS |
Group B (n = 18) Obese Patients |
Group C (n = 10) Control |
|
|---|---|---|---|
| Demographics | |||
| Age | 64 ± 3 | 72 ± 3 | 72 ± 3 |
| Height (cm) | 173 ± 2 | 169 ± 3 | 175 ± 2 |
| Weight (kg) | 87 ± 4 * | 107 ± 6 + | 81 ± 2 |
| BMI (kg/m2) | 29 ± 1 * | 38 ± 2 + | 27 ± 1 |
| Male | 68% | 50% | 90% |
| Cardiovascular presentation | |||
| MAD (mmHg) | 78 ± 2 | 76 ± 2 + | 84 ± 3 |
| HR (bpm) | 85 ± 4 | 85 ± 3 | 87 ± 4 |
| SpO2 (%) | 96 ± 1# | 98 ± 0 | 98 ± 0 |
| etCO2 (mmHg) | 42 ± 1# | 41 ± 1 | 37 ± 2 |
| Norepinephrine μg/kgKG/min | 0.24 ± 0.05 | 0.17 ± 0.03 | 0.24 ± 0.06 |
| Ventilatory parameter | |||
| FiO2 (%) | 44 ± 2 *,# | 39 ± 1 | 38 ± 1 |
| VT (mL) | 424 ± 6 | 414 ± 6 | 433 ± 6 |
| VT (mL/kg pbw) | 6 ± 0 * | 7 ± 0 + | 6 ± 0 |
| RR (/min) | 19 ± 0 # | 19 ± 0 + | 18 ± 0 |
| MV (L/min) | 9 ± 0 | 9 ± 0 | 8 ± 0 |
| PEEP (cmH2O) | 14 ± 1 # | 15 ± 1+ | 11 ± 1 |
| PInsp (cmH2O) | 27 ± 1 *,# | 30 ± 1+ | 24 ± 1 |
| ∆P (cmH2O) | 12 ± 1 * | 15 ± 1 | 13 ± 0 |
| CStat (cmH2O) at PEEP 5 (cmH2O) | 60 ± 20 | 58 ± 22 | 62 ± 23 |
| Gas exchange | |||
| pH | 7,3 ± 0 # | 7,3 ± 0+ | 7,4 ± 0 |
| paCO2 (mmHg) | 59 ± 2 *,# | 51 ± 2 | 50 ± 2 |
| paO2 (mmHg) | 93 ± 3 * | 106 ± 3 | 96 ± 5 |
| P/F ratio | 210 ± 18 | 244 ± 15 | 232 ± 11 |
BMI = body mass index; MAD = mean arterial pressure; mmHg = millimeter of mercury; HR = Heart rate; bpm = beats per minute; SpO2 = saturation of oxygen; etCO2 = end-expiratory carbon dioxide; FiO2 = inspired oxygen concentration; VT = tidal volume; pbw = predicted body weight; RR = respiratory rate; MV = minute ventilation; PEEP = positive end-expiratory pressure; Pinsp = peak inspiratory pressure; ∆P = driving pressure; CStat = static lung compliance; paCO2 = partial arterial pressure of carbon dioxide; paO2 = partial arterial pressure of oxygen; P/F ratio = ratio between partial arterial pressure of oxygen to FiO2. * p < 0.05 group A vs. group B, # p < 0.05 group A vs. group C, + p < 0.05 group B vs. group C.