Table 1.
EC50 (µM) values of compound 1, and hybrid 8-hydroxyquinoline-indole derivatives 7a–7e, 12a–12b and 18a–18h against self-induced Aβ1–42 aggregation in thioflavin T (ThT)-fluorescence assays.
| Compd. | 1 | 7a | 7b | 7c | 7d | 7e | 12a | 12b |
|---|---|---|---|---|---|---|---|---|
| Aβ1–42 | 9.95 | 4.26 | 9.28 | 3.22 | 6.34 | 9.52 | >10 | >10 |
| Compd. | 18a | 18b | 18c | 18d | 18e | 18f | 18g | 18h |
| Aβ1–42 | >10 | >10 | 1.72 | 1.48 | 2.49 | 1.08 | >10 | 2.58 |