. 2020 Aug 5;12(8):2183. doi: 10.3390/cancers12082183

Table 1.

Acid adaptation-upregulated genes significant in OS analysis in at least two types of cancers.

				Types of Cancer
Gene Name	Log₂FC	FDR	Correlation with Poor OS	PAAD	BRCA	LUAD	GBM	COAD	OV	THCA	STAD	Molecular Function/Biological Process (UniProt)
4 OVERLAPS
SMAD9	1.1723	0.0091	Low expression									DNA-binding, transcription regulation
3 OVERLAPS
LGR4	0.7849	0.0127	High expression									Differentiation, immunity
RARG	0.6840	0.0117	High expression									DNA-binding, transcription regulation
PNISR	0.5890	0.0258	Low expression									RNA-binding
PCOLCE2	0.5538	0.0408	High expression									Collagen biosynthesis
RALGDS	0.5128	0.0249	Low expression									GTPase regulator, signal transduction
2 OVERLAPS
SCNN1A	2.0490	0.0100	High expression									Ion transport
PLA2R1	1.6361	0.0249	High expression									Endocytosis
PDK4	1.6088	0.0351	High expression									Ser/Thr protein kinase, metabolism
SNED1	1.5574	0.0302	High expression									Cell-matrix adhesion
ADAMTSL4	1.5083	0.0176	High expression									Peptidase, apoptosis
RAMP1	1.4724	0.0169	High expression									Transport, angiogenesis
MFAP2	1.3770	0.0154	High expression									Embryonic morphogenesis
HSPG2	1.2833	0.0073	High expression									Angiogenesis, morphogenesis,
GNG7	1.2239	0.0142	Low expression									GTPase activity
HOXA11	1.1569	0.0346	High expression									DNA-binding, transcription regulation
ALDH3B1	1.1061	0.0081	High expression									Oxidoreductase, metabolism
CORO2A	1.0708	0.0321	High expression									Actin-binding, signal transduction
LRP1	1.0403	0.0380	High expression									Endocytosis
TMEM8B	0.9897	0.0045	Low expression									Cell adhesion, growth regulation
ZNF710-AS1	0.9413	0.0330	Low expression									lncRNA
PYGL	0.8856	0.0251	High expression									Transferase, metabolism
TMED7-TICAM2	0.8634	0.0325	High expression									Golgi organization, protein transport
NPEPL1	0.8764	0.0117	Low expression									Aminopeptidase
SMARCD3	0.8743	0.0058	Low expression									Chromatin regulator, neurogenesis
RHOBTB1	0.8684	0.0234	Low expression									GTPase activity, actin organization
UNC13D	0.8587	0.0368	High expression									Exocytosis
DBP	0.8034	0.0249	Low expression									DNA-binding, transcription regulation
PDCD4	0.7330	0.0077	Low expression									RNA-binding, apoptosis
MTMR7	0.7273	0.0329	Low expression									Phosphatase
OTX1	0.6797	0.0091	High expression									DNA-binding, morphogenesis
TXNRD3	0.6584	0.0125	High expression									Differentiation, electron transport
PPOX	0.6399	0.0279	Low expression									Oxidoreductase, heme biosynthesis
SPAG4	0.6392	0.0404	High expression									Differentiation, spermatogenesis
ANO7	0.6260	0.0329	Low expression									Lipid transport
FAHD2B	0.6164	0.0069	High expression									Hydrolase
ORAI3	0.6063	0.0224	Low expression									Calcium channel
NOP53	0.5938	0.0156	High expression									Host-virus interaction, ribosome biogenesis
C17orf49	0.5910	0.0081	Low expression									Chromatin regulator, DNA-binding
VAMP2	0.5901	0.0073	Low expression									Exocytosis, protein transport
ZNF487	0.5872	0.0377	Low expression									DNA-binding, transcription regulation
TDRD3	0.5832	0.0058	Low expression									Chromatin regulator, RNA-binding
FRG1HP	0.5302	0.0376	Low expression									Pseudogene
PLD2	0.5226	0.0306	High expression									Hydrolase, lipid metabolism, motility
MLLT6	0.5118	0.0038	Low expression									Histone-binding, metal ion-binding

PAAD—pancreatic cancer (dark blue), BRCA—breast cancer–luminal B (pink), LUAD—lung cancer–adenocarcinoma (turquoise), GBM—glioblastoma (orange), COAD—colon cancer (red), OV—ovarian cancer (purple), THCA—thyroid cancer (grey), STAD—stomach cancer (green). Molecular function and/or biological processes according to UniProt database [48].