. 2020 Aug 5;12(8):2183. doi: 10.3390/cancers12082183

Table 2.

Acid adaptation-upregulated genes significant in OS analysis in at least two types of cancers.

				Types of Cancer
Gene Name	Log₂FC	FDR	Correlation with Poor OS	PAAD	BRCA	LUAD	GBM	COAD	OV	THCA	STAD	Molecular Function/Biological Process (UniProt)
5 OVERLAPS
ZNF557	−0.5999	0.0069	Low expression									DNA-binding, transcription factor, metal on binding
3 OVERLAPS
MDGA1	−1.2003	0.0153	High expression									Differentiation, neurogenesis
VEGFC	−0.8963	0.0345	High expression									Growth factor, angiogenesis, differentiation
MCM10	−0.8486	0.0249	High expression									DNA-binding, DNA replication, DNA damage
CTBP1-DT	−0.5490	0.0098	Low expression									Oxidoreductase, differentiation, transcription
CHMP4A	−0.5182	0.0247	Low expression									Protein transport
2 OVERLAPS
CGN	−1.5661	0.0112	High expression									Tight junction regulation
AKAP5	−1.4671	0.0408	Low expression									Calmodulin-binding
HIST1H4H	−1.3143	0.0276	High expression									DNA-binding
STYK1	−1.0844	0.0290	High expression									Protein tyrosine kinase
CDC25A	−1.0023	0.0182	Low expression									Protein phosphatase, cell cycle, cell division
RRM2	−0.9925	0.0325	High expression									Oxidoreductase, DNA replication
VDR	−0.9901	0.0131	High expression									Vitamin D3 receptor, DNA-binding, transcription
CDC6	−0.8805	0.0110	High expression									Cell cycle, cell division, DNA replication
GINS4	−0.8574	0.0376	High expression									DNA replication
AC019069.1	−0.8118	0.0467	High expression									lncRNA
TCF19	−0.7835	0.0296	High expression									DNA-binding, transcription factor
GINS2	−0.7784	0.0182	Low expression									DNA replication
SOWAHC	−0.7653	0.0201	High expression									Ankyrin repeat domain-containing protein
BRCA2	−0.7332	0.0375	High expression									DNA-binding, DNA recombination, DNA damage
AC092279.1	−0.6853	0.0203	Low expression									lncRNA
CDCA5	−0.6652	0.0425	High expression									Cell cycle, cell division
TUBB2A	−0.6559	0.0360	High expression									GTP-binding, microtubule cytoskeleton organization
OAS3	−0.6518	0.0117	High expression									RNA-binding, antiviral defense, immunity
SFN	−0.6382	0.0158	High expression									DNA damage response
MTHFD1	−0.6333	0.0107	High expression									Embryonic morphogenesis
ZNF562	−0.6041	0.0069	Low expression									DNA-binding, transcription factor, metal ion binding
MASTL	−0.6008	0.0482	High expression									Ser/Thr protein kinase, cell division
CDCA4	−0.5907	0.0236	High expression									Cell division
MMS22L	−0.5725	0.0418	Low expression									DNA repair
RMI1	−0.5661	0.0443	Low expression									DNA replication
C1orf112	−0.5581	0.0415	High expression									Uncharacterized protein C1orf112
MIR4435-2HG	−0.5537	0.0105	High expression									lncRNA
MCM4	−0.5328	0.0482	High expression									DNA-binding, cell cycle, DNA replication
DSCC1	−0.5268	0.0492	High expression									DNA-binding, cell cycle, DNA replication
USP1	−0.5192	0.0330	Low expression									Protease, DNA repair
MCM3	−0.5129	0.0471	Low expression									Transferase, mRNA transport, immunity
EIF6	−0.5008	0.0100	High expression									Ribosome biogenesis, protein synthesis

PAAD—pancreatic cancer (dark blue), BRCA—breast cancer–luminal B (pink), LUAD—lung cancer–adenocarcinoma (turquoise), GBM—glioblastoma (orange), COAD—colon cancer (red), OV—ovarian cancer (purple), THCA—thyroid cancer (grey), STAD—stomach cancer (green). Molecular function and/or biological processes according to UniProt database [48].