Figure 5.

Cumulative permeation (%) of tobramycin (Tob) penetrating through 24 h-old PA14 wt biofilms normalized to the permeation of free Tob through the bare transwell membrane, pore size 400 nm. *, # are for p < 0.001 vs. concentrations measured at 0 and 0.5 h, respectively; and §, &, β are for p < 0.001 vs. concentrations measured at 0, 0.5 and 1 h, respectively; δ are for p < 0.05 paired comparison of Tob biofilm penetrating concentrations with and without IA measured at 3 and 6 h. n = 3 experiments with technical triplicates each.