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The sperm proteome of Prm2-deficient mice. (A) Venn diagrams showing the overlap of the generated dataset with published datasets of murine and human sperm. (B) Principal component analysis (PCA). MS comprised three biological replicates per genotype. Contribution of each dataset to the PCA is reflected by the dot size. (C) Heatmap visualization of the top 50 most significantly deregulated proteins (|log2 FC| > 1; FDR < 0.05) between Prm2+/+, Prm2+/− and Prm2−/− samples.
