Table 2.
Monotherapy | Integrative Therapy | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
n | Events | Person-Year | Incidence a | n | Events | Person-Year | Incidence | Crude HR (95% CI) | Adjusted b HR (95% CI) | |
All | 411 | 25 | 2968 | 8.4 | 1405 | 55 | 10890 | 5.1 | 0.60 (0.37–0.96) | 0.56 (0.34–0.92) |
Sex | ||||||||||
Male | 242 | 13 | 1718 | 7.6 | 526 | 19 | 3980 | 4.8 | 0.63 (0.31–1.28) | 0.57 (0.28–1.17) |
Female | 169 | 12 | 1249 | 9.6 | 879 | 36 | 6910 | 5.2 | 0.54 (0.28–1.04) | 0.58 (0.29–1.14) |
Age | ||||||||||
<65 | 197 | 8 | 1607 | 5.0 | 664 | 20 | 5489 | 3.6 | 0.73 (0.32–1.66) | 0.77 (0.33–1.82) |
≥65 | 214 | 17 | 1361 | 12.5 | 741 | 35 | 5392 | 6.5 | 0.52 (0.29–0.92) | 0.51 (0.28–0.94) |
Medication use | ||||||||||
0 | 112 | 7 | 806 | 8.7 | 273 | 14 | 2084 | 6.7 | 0.77 (0.31–1.92) | 0.79 (0.30–2.08) |
1 | 299 | 18 | 2162 | 8.3 | 1132 | 41 | 8607 | 4.7 | 0.56 (0.32–0.97) | 0.54 (0.30–0.96) |
a Per 1000 person-years; b Model adjusted for sex, age, alcohol, cardiovascular, chronic kidney, chronic obstructive pulmonary disease, dementia, depression, diabetes mellitus, hyperlipdemial, hypertension, medication use, hospitalization medical use, outpatient medical use, and number of hospitals visited. HR: hazard ratio.