Table 1.

A ClinicalTrials.gov search found 12 ongoing national coordinated trials (NCTs) involving exosomes as MSC-based therapeutic agents from different sources and a further 2 NCTs involving plasma-derived and T cell exosomes.

Sponsor, City and State	NCT No	Disease	Exo Source
Wuhan Jinyintan Hospital, Wuhan, China	NCT04276987	Severe novel coronavirus pneumonia	Mesenchymal stem cells (MSCs)
Beni-Suef University, Bani Sweif, Egypt	NCT04270006	Periodontitis	MSCs
Fujian Medical University, Fujian, China	NCT04356300	Multiple organ dysfunction syndrome	MSCs
TC Erciyes University, Talas, Turkey	NCT04389385	Severe novel coronavirus pneumonia	T Cell
Sun Yat-sen University, Guangzhou, China	NCT04213248	Dry eye in patients with chronic graft-versus-host disease (cGVHD)	MSCs
M.D. Anderson Cancer Center, Houston, TX, USA	NCT03608631	Metastatic pancreas cancer with KrasG12D mutation	MSCs
El Sahel Teaching Hospital, Cairo, Egypt	NCT02138331	Type 1 diabetes (T1DM)	MSCs
Ruijin Hospital, Shanghai, China	NCT04313647	Clinical tolerance in healthy volunteers	MSCs
Tianjin Medical University, Tianjin, China	NCT03437759	MSC-Exo promotes MH healing	MSCs
Ruijin Hospital, Shanghai, China	NCT04388982	Alzheimer’s disease	MSCs
Aegle Therapeutics, Arlington, MA, USA	NCT04173650	Dystrophic epidermolysis bullosa	MSCs
Stem Cell and Cancer Institute, Kalbe Farma, Jakarta, Indonesia	NCT04134676	Chronic ulcer wounds	MSCs
Neurological Associates of West Los Angeles, CA, USA	NCT04202783	Craniofacial neuralgia	MSCs
Kumamoto University, Kumamoto, Japan	NCT02565264	Cutaneous wound healing	Plasma
Saeed Oraei Yazdani, Tehran, Iran	NCT03384433	Acute ischemic stroke	MSCs
Neurological Associates of West Los Angeles, CA, USA	NCT04202770	Depression, anxiety and dementias	MSCs