Figure 7.

In 10–13 days from injection, C26 growth in mice causes atrophy and dysfunction of multiple tissues that are not fully reversed by ET743 or PM01183. PBS-injected mice were used to measure multiple parameters and plotted as 100% at the extremity of the scheme. Weights of five muscles (TA, soleus, gastrocnemius indicated as gastroc, diaphragm and heart), thickness and excursion of the diaphragm, shortening fraction (SF) and left ventricular ejection fraction (LVEF) for the heart, evaluated using ultrasound-based imaging, and fat content using micro-CT, are reported as percentages of controls in C26-bearing mice in blue, in PM01183-treated C26 mice in green and in ET743-treated mice in red (10/group).