Table 1.
Fecal miRNAs as diagnostic biomarkers for colorectal cancer (CRC).
| Fecal miRNAs | Expression Level CRC VS. HC | Ref |
|---|---|---|
| miR-17-92 cluster * | Up | [137] |
| miR-20a | Up | [151] |
| miR-21 | Up | [82,135,139,152,153,154,155] |
| miR-135 | Up | [118,137] |
| miR-144 | Up | [155,156] |
| miRNA-146a | Down, although not significant | [139] |
| miR-29a | Down | [140] |
| miR-223 | Up | [156] |
| miR-223 | Down | [140] |
| miR-34a | methylation | [157] |
| miR-34b/c | methylation | [157] |
| miR-221 | Up | [138] |
| miR-92a | Up | [135,139,153,154,155,158] |
| miR-224 | Down | [140] |
| miR-106a | Up | [81,82,153] |
| miR-106b | Up | [82] |
| miR-143 | Down | [159] |
| miR-145 | Down | [159] |
| miR-4478 | Down | [160] |
| miR-135b | Up | [118] |
| miR-1295b-3p | Down | [160] |
| 3 types miRNAs | Up-regulated miR421, miR130b-3p, and miR27a-3p | [161] |
| 14 types miRNAs | Up-regulated miR-21, -106a, -96, -203, -20a, -326 -92 Down-regulated miR-320, -126, -143, -484-5p, -16, -145 -125b | [81] |
| 20 types miRNAs | Up-regulated miR-7, miR-17, miR-20a, miR-21, miR-92a, miR-96, miR-106a, miR-134, miR-183, miR-196a, miR-199a-3p, miR-214Down-regulated miR-9, miR-29b, miR-127-5p, miR-138, miR-143, miR-146a, miR-222, miR-938 | [134] |
Up and Down indicate Up-regulated and Down-regulated miRNA expression in a population with CRC compared with healthy volunteers, respectively. CRC: Colorectal Cancer; miRNA: microRNA; HC: Healthy Control. * The miR-17-92 cluster includes miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a.