Figure 1.

TPs cluster with certain types of HA-RAMPs (helical amphiphilic ribosomally-synthesized AMPs (antimicrobial peptides)). (A) Contribution of the different groups of peptides, as described by 36 auto-cross covariance (ACC) terms, to the 2 clusters obtained by k-means (Chi² Pearson test, p < 4.94 × 10⁻³²⁴). The average silhouette coefficient is indicated above the graph. HA-RAMPs are depicted in blue in cluster 1 and in red in cluster 2. (B) Proportion of peptides among the 2 clusters for each group. Total number of peptides is indicated above bars. See figure panel for color code. (C) Percentage of peptides from the HA-RAMP families described in the literature among classes I and II. Total number of peptides is indicated above bars, in parenthesis.