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. 2020 Jul 24;12(8):2042. doi: 10.3390/cancers12082042

Figure 1.

Figure 1

Illustration of the Hippo pathway and its regulation in mammalian cells. Yes-associated protein (YAP) and TAZ complex with TEAD can activate several cellular functions in the nucleus. The Hippo pathway function is to prevent YAP/TAZ activity by phosphorylating them, which causes their cytoplasmic retention, by 14–3–3 proteins, or their ubiquitination, by the Skp, Cullin, F-box (SCF) complex. The regulation of the Hippo pathway by upstream membrane receptors is not a comprehensively studied topic.