Figure 3.

Emerging understanding of how T cell signal strength might determine T cell fate through integrating NFAT with AP1 transcription factors and regulating master transcription factor regulators, such as TOX. A canonical AP1 transcription factor is shown as c-JUN/c-FOS heterodimer. Oblong boxes represent consensus binding sites in promoters. The concept of “partner-less NFAT” is depicted as NFAT binding to its consensus with no AP1 family transcription factors bound to adjacent AP1 site. The extent to which this phenomenon is determined by high NFAT versus absence of AP1 binding transcription factors is not fully understood.