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. 2020 Jul 31;10(8):1131. doi: 10.3390/biom10081131

Table 1.

Direct arylation and subsequent allylation.

graphic file with name biomolecules-10-01131-i001.jpg
Entry X R1 Product Yield (%) Product Yield (%)
1 O 4-OMOM 18a 60% 16a 69%
2 O 4-OH 18b n.s. 16b 91% 1
3 O 4-OMe 18c 58% 16c 70%
4 O 3,5-dimethoxy 18d 51% 16d 66%
5 O H 18e 44% 16e 74%
6 O 4-F 18f 41% 16f 72%
7 O 4-CHF2 18g 45% 16g 69%
8 O 2-Cl 18h 44% 16h 51%
9 S 4-OMOM 22a 58% 23a 46%
10 S 4-OMe 22c 31% 23c 58%

n.s. not synthesized; 1 via MOM-deprotection from 16a, the yield refers only to the deprotection step.