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Flow chart of patient selection. * Inclusion criteria: patients ≥ 18 years, with an Eastern cooperative oncology group (ECOG) performance status ≤ 2 and RAS wild-type tumors. Patients had to be sensitive (patients achieving complete or partial response at the first CT-scan or disease stabilization lasting at least 6 months) or resistant to anti-EGFR blockade (patients showing disease progression at the first CT-scan).
