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Cellular targets of viral UbL deconjugases. Viral UbL deconjugases target different steps of the innate antiviral response, ultimately leading to inactivation of the NF-κB, IRF3 and IRF7 transcription factors and inhibition of the production of inflammatory cytokines and type I IFNs. In addition, nuclear targets of the deconjugases encoded by DNA viruses regulate viral DNA replication and activation of the DNA damage response.
