Table 1.
UbL deconjugases encoded by human viruses.
| Virus | Viral Protein | Specificity | Viral Substrates | Cellular Substrates |
Ref. |
|---|---|---|---|---|---|
| Adenoviridae | |||||
| Adenovirus (AdV) | Adenain/AVP (UCH/SENP-like) |
K48/K63poly-Ub, ISG15 | capsid proteins | Histone H2A? | [86,87] |
| Herpesviridae | |||||
| Herpes simplex virus (HSV1, HHV1) | UL36 | K48/K63poly-Ub, Nedd8 | UL36 | TRAF3, IkBa, PCNA, | [88,89,90,91,92] |
| Cytomegalovirus (HCMV, HHV5) | UL48 | K48/K63poly-Ub, Nedd8 | UL48 | RIP1 | [93,94,95,96] |
| Epstein-Barr virus (EBV, HHV4) | BPLF1 | K48/K63poly-Ub, Nedd8 | RR1 | Cullins, PCNA, Rad6/18 TRAF6, IκBα; NEMO, TRIM25 | [85,97,98,99,100] |
| Kaposi sarcoma herpesvirus (KSHV, HHV8) | ORF64 | K48/K63poly-Ub, Nedd8 | ? | RIG-I | [101,102] |
| Coronaviridae | |||||
| Severe acute respiratory syndrome coronavirus (SARS-CoV) | PLpro (USP-like) |
K48poly-Ub, ISG15 | polyprotein | RIG-I, TRAF3, STING, TBK1, IRF3 | [103,104,105] |
| Middle east respiratory syndrome coronavirus (MERS-CoV) | PLpro (USP-like) |
all type of poly-Ub, ISG15 | polyprotein | RIG-I | [106] |
| New severe acute respiratory syndrome coronavirus (SARS-CoV-2) | PLpro (USP-like) |
K48poly-Ub, ISG15 | polyprotein | IRF3 | [107,108,109] |