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Effect of a high-fat diet (HFD) on hepatic fibrosis. High-fat diet treatment increased collagen deposition in the liver, indicated by a higher intensity of Sirius red staining. This fibrosis was prevented in animals treated with MESK (Magnification 10×). (A) Normal diet, (B) high-fat diet, (C) HFDO: HFD + Orlistat, and (D) HFDM: HFD + MESK. Scale bar indicates 50 µm.
