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The impact of high-fat diet treatment on Nesfatin-1/NUCB-2 expression in mouse jejunum using immunofluorescence. HFD-fed mice showed lower expression of satiety molecule Nesfatin-1 in the mouse jejunum (arrows). Treatment with MESK and Orlistat increased the expression of Nesfatin-1 (arrows). (A) ND: normal diet, (B) HFD: high-fat diet, (C) HFDO: HFD + Orlistat, and (D) HFDM: HFD + MESK.
