Table 1.

Altered microRNAs (miRNAs) regulating key signaling pathways in rectal cancer.

Pathway	MiRNA	Role	Putative Target	References
PI3K/Akt	miR-141-3p	Oncogenic	PTEN	[30]
	miR-375	Oncogenic	Klf5	[31]
	miR-126	Oncogenic	p85β	[32]
	miR-21	Oncogenic	PTEN	[33]
EGFR	let-7 family	Tumor suppressor	Ras and Myc	[34]
	mir-143	Tumor suppressor	Ras	[33]
Wnt	miR-101-3p	Tumor suppressor	β-catenin and TCF4	[35]
	miR-135a/b	Oncogenic	APC	[36]
IGFR	miR-145	Tumor suppressor	IRS-1	[37]
			IGF-IR	[38]
	miR-195	Tumor suppressor	IGF1	[27]
Other signaling pathways	miR-125a-5p	Tumor suppressor	BCL2, BCL2L12 and Mcl-1	[39]
	miR-21	Oncogenic	RECK and TIMP3	[40]
			SATB1	[41]
			SPRY2	[42]
			cdc25a	[43]