Table 2.
Comparison of disease severity, IBS-QoL overall score, Bristol Stool Chart, serum zonulin levels and cytokines values, assessed at baseline (T0), between the two groups of patients treated with B. Longum ES1 for 8 or 12 weeks.
| Parameters | T0 (8w) | T0 (12w) | p Values |
|---|---|---|---|
| Patients (n) | 8 | 8 | |
| Disease severity (mild/moderate/severe) | 1/2/5 | 0/6/2 | 0.248 |
| IBS-QoL overall score (mean ± SD) | 65 ± 17 | 78 ± 13 | 0.118 |
| Bristol Stool Scale (mean ± SD) | 6 ± 1 | 7 ± 1 | 0.150 |
| Zonulin (ng/mL, mean ± SD) | 41.1 ± 11.60 | 43.8 ± 6.8 | 0.570 |
| IL-6 (pg/mL, median, 95% CI) | 3.26, 2.58–5.01 | 6.77, 3.50–10.09 | 0.060 |
| IL-8 (pg/mL, median, 95% CI) | 3.46, 1.55–5.77 | 3.78, 1.55–5.99 | 0.670 |
| IL-12p70 (pg/mL, median, 95% CI) | 1.37, 0.57–3.68 | 1.77, 0.57–2.16 | 0.830 |
| TNFα (pg/mL, median, 95% CI) | 5.69, 0.47–10.70 | 7.99, 0.38–15.06 | 0.460 |
Abbreviations: interleukin (IL), confidence interval (CI), number (n), non-responder (NR), responder (R), standard deviation (SD), tumour necrosis factor-alpha (TNFα), week (w).