Table 3.
Changes of questionnaires scores, serum zonulin levels and cytokines values from T0 to T1 in the overall study population.
| Parameters | T0 | T1 | p Values |
|---|---|---|---|
| Patients (n) | 16 | 16 | |
| IBS-SSS (mean ± SD) | 289 ± 91 | 263 ± 118 | 0.103 |
| Pain intensity (mean ± SD) | 57 ± 28 | 47 ± 31 | 0.216 |
| Bloating (mean ± SD) | 39 ± 30 | 44 ± 32 | 0.340 |
| IBS-QoL overall score (mean ± SD) | 71 ± 16 | 73 ± 17 | 0.299 |
| Bristol Stool Scale (mean ± SD) | 6 ± 1 | 4 ± 1 | <0.001 * |
| Zonulin (ng/mL, mean ± SD) | 42.5 ± 9.3 | 40.5 ± 6.8 | 0.179 |
| IL-6 (pg/mL, median, 95% CI) | 4.22, 2.87–7.06 | 0.01, 0.01–3.65 | <0.001 * |
| IL-8 (pg/mL, median, 95% CI) | 3.47, 1.96–5.32 | 0.01, 0.01–1.12 | 0.011 * |
| IL-12p70 (pg/mL, median, 95% CI) | 1.77, 0.57–2.16 | 0.01, 0.01–0.21 | 0.001 * |
| TNFα (pg/mL, median, 95% CI) | 5.69, 2.23–11.09 | 0.01, 0.01–5.69 | 0.034 * |
Abbreviations: confidence interval (CI), interleukin (IL), Irritable Bowel Syndrome Quality of Life (IBS-QoL), Irritable Bowel Syndrome Severity Scoring System (IBS-SSS), number (n), standard deviation (SD), tumour necrosis factor-alpha (TNFα), statistically significant (*).