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. 2020 Aug 7;11(8):902. doi: 10.3390/genes11080902

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Joint molecules (JMs) and late replication intermediates (LRIs) can be disentangled by the BLM-TOP3A-RMI1/2 (BTR) complex or cleaved by structure-specific endonucleases (SSEs). (A) JMs can undergo BTR-mediated dissolution (top) or SSE-mediated resolution (bottom). Arrows indicate the possible sites of cleavage by nucleases. Dissolution always results in non-crossover products (NCO), whereas resolution can result in either crossover (CO) or non-crossover products. (B) LRIs can be processed by the BTR complex (top) or by structure-specific endonucleases (SSEs, bottom), leading to single-stranded DNA (ssDNA) gaps or ssDNA overhangs, respectively.