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. 2020 Aug 8;10(8):1163. doi: 10.3390/biom10081163

Figure 3.

Figure 3

Variations in metabolites consumed (negative bars) and excreted (positive bars) by cells upon exposure to triterpenic acids (TAs), as assessed by comparison to acellular culture media. Consumption and excretion patterns are shown for control cells and: (A) MDA-MB-231 treated with betulinic acid (BA) for 48 h, (B) MDA-MB-231 treated with BA for 48 h followed by 24 h recovery in fresh medium, (C) MDA-MB-231 treated with ursolic acid (UA) for 48 h followed by 24 h recovery in fresh medium, (D) MCF-10A treated with BA for 48 h, (E) MCF-10A treated with BA for 48 h followed by 24 h recovery in fresh medium, (F) MCF-10A treated with UA for 48 h, (G) MCF-10A treated with UA for 48 h followed by 24 h recovery in fresh medium. Four independent replicates considered. ** p-value < 0.01; * p-value < 0.05. Three-letter code used for amino acids. Different scale used in each graph according to variation range.