Table 3.

Toxicity and side effect-causing protein target of drugs.

Protein	Physiological Function	Site of Action	Effect of Deficiency/Inhibition	Ref.
pyruvate kinase	glycolysis	cytosol	hemolytic anemia	[44]
aconitase	citric acid cycle	mitochondria	neurotoxicity	[45]
cytochrome c	oxidative phosphorylation	mitochondria	increased sensitivity to cell heath signals triggered by TNF-α	[46]
carbamoyl phosphate synthetase I	urea cycle	mitochondria	hyperammonemia	[47]
hypoxanthine-guanine phosphoribosyltransferase	nucleotide biosynthesis	mitochondria	hyperuricemia	[48]
glutamate dehydrogenase	amino acid degradation	mitochondria	nephrotoxicity	[49]