Table 3.
Viscosity of oil and aqueous phases and corresponding emulsion particle size.
| Description * | Viscosity (cP) ** | Emulsion Particle Diameter (Z-Ave, nm) after 3 Passes (see Figure 2a) |
|---|---|---|
| Oil phase | 14.8 | N/A |
| Aqueous phase for 4% SE | 1.4 | 141.5 ± 3.6 |
| Aqueous phase for 10% SE | 1.3 | 132.4 ± 2.1 |
| Aqueous phase for 20% SE | 1.7 | 125.4 ± 1.4 |
| Aqueous phase for 30% SE | 2.3 | 88.5 ± 1.5 |
| Aqueous phase for 30% SE (no glycerol) | 1.4 | 120.2 ± 0.9 |
| Aqueous phase for 40% SE | 3.9 | 76.6 ± 0.4 |
* The specific volume of DMPC was not accounted for, thus the concentration of DMPC and other aqueous phase excipients may have varied between ~1–13% from the target concentrations [13]. ** Viscosity was measured prior to addition of DMPC; DMPC impacts viscosity of both oil and aqueous phases.