Table 6.
Results of DLS measurements after 12 months of physical-stability examination.
| Sampling (Month) | Z-Average * (nm) | PdI * |
|---|---|---|
| 0 | 100.47 ± 0.87 | 0.149 ± 0.01 |
| 1 | 100.79 ± 0.51 | 0.151 ± 0.04 |
| 2 | 100.88 ± 0.82 | 0.152 ± 0.02 |
| 3 | 100.85 ± 1.03 | 0.152 ± 0.03 |
| 4 | 101.05 ± 0.41 | 0.153 ± 0.05 |
| 5 | 101.11 ± 0.93 | 0.155 ± 0.01 |
| 6 | 101.19 ± 0.48 | 0.154 ± 0.04 |
| 7 | 101.22 ± 0.21 | 0.154 ± 0.06 |
| 8 | 101.79 ± 0.81 | 0.156 ± 0.07 |
| 9 | 101.76 ± 1.15 | 0.160 ± 0.04 |
| 10 | 101.94 ± 0.77 | 0.161 ± 0.03 |
| 11 | 102.56 ± 0.42 | 0.163 ± 0.08 |
| 12 | 103.78 ± 0.36 | 0.165 ± 0.04 |
| absolute change | +3.31 | +0.016 |
* Data are means ± SD (n = 3 independent formulations).