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. 2020 Aug 3;9(8):203. doi: 10.3390/biology9080203

Figure 3.

Figure 3

GPR43 antagonist inhibits the improvement of DM symptoms by exercise. (A) After the T2DM model was established, all diabetic mice were challenged with GLPG0974 and the body weight of mice in each group was measured; (B) fasting blood glucose in each group were determined by a OneTouch Ultra blood glucose meter; (C) insulin levels in mice of each group as detected by ELISA kit; (D) fasting blood glucose was performed after glucose administration for 15, 30, 60, 90 and 120 min and the curve of oral glucose tolerance test (OGTT) was made; (E) area under glucose tolerance curve in each group; (F) fasting blood glucose level was determined after insulin injection for 15, 30, 60, 90 and 120 min and a tolerance test (ITT) was created; (G) area under the insulin tolerance curve in different groups; (H) food intake in control mice, diabetic mice treated with or without exercise and diabetic mice treated with or without GLPG0974. ** p < 0.01.