Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 15;12(8):2298. doi: 10.3390/cancers12082298

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

AT101 sensitizes carcinoma cells to other BH3 mimetics. (A) HCT116 cells and (B) MiaPaca2 cells were incubated with either ABT-263, ABT-199 or A1155463 alone or in combination with 10 µM AT101 for 6 h. (C) HCT116 cells were transfected with non-targeting siRNA (siCtrl) or siRNA against NOXA (siNOXA) then incubated with either 5 µM A1155463, 10 µM AT101 or both for 6 h. Apoptosis was assessed by PARP cleavage and chromatin condensation, expressed as the percentage of surviving cells (n = 3, error bars represent standard deviation, ** p < 0.01). (D) HCT116 cells were incubated with 10 µM QVD for 1 h and then with A1155463 alone or in combination with 10 µM AT101 for 6 h.

AT101 sensitizes carcinoma cells to other BH3 mimetics. (A) HCT116 cells and (B) MiaPaca2 cells were incubated with either ABT-263, ABT-199 or A1155463 alone or in combination with 10 µM AT101 for 6 h. (C) HCT116 cells were transfected with non-targeting siRNA (siCtrl) or siRNA against NOXA (siNOXA) then incubated with either 5 µM A1155463, 10 µM AT101 or both for 6 h. Apoptosis was assessed by PARP cleavage and chromatin condensation, expressed as the percentage of surviving cells (n = 3, error bars represent standard deviation, ** p < 0.01). (D) HCT116 cells were incubated with 10 µM QVD for 1 h and then with A1155463 alone or in combination with 10 µM AT101 for 6 h.