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. 2020 Aug 5;12(8):2182. doi: 10.3390/cancers12082182

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The combination-induced cell death was partially dependent on NOXA, BCL2-like 11 (apoptosis facilitator) (BIM) or BID. ATP assays with knockdown (KD) or knock out (KO) of indicated cells to test if the KD/KO protects against combination-induced cell death. Immunoblot to show the knockdown or knockout of NOXA, BIM or BID. (a) KD lines for NOXA, BIM, or BID in A375. (b) KD lines for NOXA in SKMEL-28. (c) BIM KO lines in WM852c. * indicates p < 0.05; ** indicates p < 0.01. Error bars represent +/− SEM.