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. 2020 Aug 4;11(8):885. doi: 10.3390/genes11080885

Figure 6.

Figure 6

Structural conservation between yeast and humans. (A) Comparison of the structures of RagA/RagC (PDB: 6S6A) and Gtr1/2 (PDB:4ARZ) complexes, with or without Ragulator for RagA/RagC, and EGO for Gtr1/2. Both GTPases are able to rotate and move their G-domains and alter the inter-G domain expanse. (B) Comparison of the Ragulator-RagA/RagC complex (PDB:6U62) and the EGO-Gtr1/2 (PDB: 6JWP) complex. Both complexes show a very similar architecture: Ragulator interacts with the CRD of RagA/RagC via LAMTOR1 and LAMTOR2, while EGO interacts with the CRD of Gtr1/Gtr2 via Ego1 and Ego3. (C) Structure of the TORC1 TOROID (EMD-3814). The intra- (black) and inter-coil (blue) interactions are indicated, with a focus on the Kog1 α-solenoid—Tor FRB interaction that occludes the FRB domain and active site. The structure of mTORC1 (PDB:6BCX) fitted in the cryo-EM map is shown.