Table 1.
Target Of Rapamycin Complex 1 and 2 (TORC1 and TORC2) components in Saccharomyces cerevisiae and humans. Mass for (m)TORC1/2 assumes two copies of each subunit per complex. The names of the complete, functional complexes are indicated with a °. The mass of mTORC1 does not include PRAS40 and DEPTOR, and that of mTORC2 does not include DEPTOR. HUGO gene nomenclature is shown below in parenthesis for proteins for which the common name differs.
| Saccharomyces cerevisiae | Molecular Weight (kDa) | Homo sapiens | Molecular Weight (kDa) |
|---|---|---|---|
| TORC1° | 1164 | mTORC1° | 948 |
| Tor1 or Tor2 | 281 | mTOR | 289 |
| Kog1 | 178 | Raptor (RPTOR) |
149 |
| Lst8 | 34 | mLst8 | 36 |
| Tco89 | 89 | - | - |
| - | - | PRAS40 (AKT1S1) |
27 |
| - | - | DEPTOR | 46 |
| TORC2° | 1436 | mTORC2° | 1152 |
| Tor2 | 281 | mTOR | 289 |
| Avo1 | 131 | mSin1 (MAPKAP1) |
59 |
| Avo2 | 47 | - | - |
| Avo3 | 164 | Rictor | 192 |
| Lst8 | 34 | mLst8 | 36 |
| Bit61 or Bit2 | 61 | Protor1 or Protor2 (PRR5) |
42 or 41 |
| - | DEPTOR | 46 |