Table 2.
(m)TORC1 regulators in Saccharomyces cerevisiae and humans. The names of the complete, functional complexes are indicated with a °. The stoichiometries of SEACAT and GATOR2 components have not yet been determined. The Rheb homolog in S. cerevisiae is not implicated in TORC1 regulation [6] and thus omitted for clarity. The molecular weight of the multi-protein complexes is shown only for those for which there is a structure available. HUGO gene nomenclature is shown below in parenthesis for proteins for which the common name differs.
| S. cerevisiae | Molecular Weight (kDa) | H. sapiens | Molecular Weight (kDa) |
|---|---|---|---|
| EGO complex° | 121 | Ragulator-Rag° | 148 |
| Gtr1 | 36 | RagA or RagB (RRAGA or RRAGB) |
37 or 43 |
| Gtr2 | 39 | RagC or RagD (RRAGC or RRAGD) |
44 or 46 |
| Ego1 | 20 | LAMTOR1/p18 | 18 |
| Ego2, possibly Ego4 | 8, 11 | LAMTOR5/HBXIP | 10 |
| Ego3 | 18 | LAMTOR2/p14 | 14 |
| - | - | LAMTOR3/MP1 | 14 |
| - | - | LAMTOR4/C7orf59 | 11 |
| - | - | Rheb | 20 |
| - | - | TSC° | 696 |
| - | - | TSC1/Hamartin | 130 |
| - | - | TSC2/Tuberin | 201 |
| - | - | TBC1D7 | 34 |
| SEACIT° | GATOR1° | 289 | |
| Iml1 | 182 | DEPDC5 | 181 |
| Npr2 | 70 | NPRL2 | 44 |
| Npr3 | 130 | NPRL3 | 64 |
| SEACAT° | GATOR2° | ||
| Sea4 | 118 | Mios | 99 |
| Sea2 | 149 | Wdr24 | 88 |
| Seh1 | 39 | Seh1L | 40 |
| Sec13 | 33 | Sec13 | 36 |
| Sea3 | 131 | Wdr59 | 110 |
| Lst7-Lst4° | FLCN-FNIP2° | 186 | |
| Lst7 | 28 | FLCN | 64 |
| Lst4 | 93 | FNIP2 | 122 |