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. 2020 Jul 26;9(8):666. doi: 10.3390/antiox9080666

Figure 3.

Figure 3

Structure of high-mobility group box 1 (HMGB1) protein. HMGB1 is a protein consisting of 216 residues, 30 kD, highly conserved among mammals. The protein contains three alpha-helices, connected together by loops. It consists of two homologous DNA-binding domains of the HMG-box type: Box A (and Box B) and segment C-terminal, a negatively charged “tail”. There are two nuclear localization sequences. Green marks the linker and terminal regions of HMGB1. Box A (P9–79) is colored in green and Box B (P89–162) in red.