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. 2020 Aug 5;9(8):712. doi: 10.3390/antiox9080712

Figure 4.

Figure 4

Effects of fenofibrate on mitochondrial damage in RF/6A cells assessed by JC-1 staining. RF/6A cells were pretreated with different concentrations of fenofibrate for 1 h, then exposed to 1 mM paraquat (PQ) for 24 h. Dose-dependent effect of fenofibrate treatment on (a) the expression of J-aggregates in PQ-stimulated RF/6A cells, and (b) JC-1 monomers in PQ-stimulated RF/6A cells. (** p < 0.01 between the control group and 1 mM PQ-stimulated group using Mann–Whitney U-test; # p < 0.05, ## p < 0.01 compared to only 1 mM PQ-stimulated group using Kruskal–Wallis test with post hoc Dunn’s test; n = 4 in each group) PQ: 1 mM PQ; F25: 1 mM PQ with 25 µM fenofibrate; F50: 1 mM PQ with 50 µM fenofibrate; F75: 1 mM PQ with 75 µM fenofibrate; F100: 1 mM PQ with 100 µM fenofibrate. (c) Fluorescence microscopy images showing the expression of JC-1 monomers (FITC) and J-aggregates (Texas Red).