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. 2020 Jul 26;11(8):854. doi: 10.3390/genes11080854

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of cartilage extracellular matrix and its changes in osteoarthritis. (A) A healthy network of proteoglycan aggregates entangled with type II collagen fibres is seen. matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) cleavage sites are represented by red arrows; (B) Cartilage matrix changes in osteoarthritis defined by degradation of proteoglycans and cleavage of type II collagen fibres by ADAMTS and MMPs, respectively.