Table 4.
Comparison of recurrence patterns among groups by number of preoperative predictable prognostic factors in patients with stage 3/4 gallbladder cancer without distant metastases.
| Type of Recurrence | 0 Factors | 1 Factor | 2 or 3 Factors | p Value Φ |
|---|---|---|---|---|
| (n = 68) | (n = 54) | (n = 35) | ||
| Any type of recurrence | 32 (47%) #, * | 38 (70%) # | 26 (74%) * | 0.007 |
| Liver | 11 (16%) # | 17/52 (33%) # | 6/33 (18%) | 0.09 |
| Lymph node | 9 (16%) | 13/52 (25%) | 5/33 (15%) | 0.23 |
| Dissemination | 10 (15%) * | 10/52 (19%) ∀ | 13/33 (39%) *, ∀ | 0.02 |
| Local | 9 (16%) | 12/52 (23%) | 8/33 (24%) | 0.61 |
| Others | 1 | 4 (44%) | 3 (83%) | 0.11 |
# p < 0.05, between 0 vs. 1 factor; * p < 0.05, between 0 vs. 2 or 3 factors; ∀p < 0.05 between 1 vs. 2 or 3 factors with Fisher exact test two sided, respectively. Φ 2 × 3 Fisher exact test two sided. Preoperatively predictable prognostic factors are defined as liver invasion ≥5 mm, invasion of the left margin, or entire area of the HDL and ≥4 regional lymph node metastases.