Table 4.
Coagulation findings on admission and final outcomes.
| PIICS | Non-PIICS (Prolonged Hospital Stay without PIICS/Early Recovery) |
Early Death | ||
|---|---|---|---|---|
| n | 488 | 4493 | 416 | p-Value |
| ISTH overt DIC (%) | 121 (24.8) a,b | 531 (11.8) c | 174 (41.8) | <0.0001 * |
| JAAM DIC (%) | 154 (31.6) a,b | 618 (13.8) c | 218 (52.4) | <0.0001 * |
| Platelet (×10,000/μL) | 18.5 (12.4, 25.0) d,e | 19.4 (14.9, 24.4) f | 16.4 (10.4, 22.3) | <0.0001 * |
| FDP (μg/dL) | 11.4 (5.7, 32.5) d,e | 4.9 (2.5, 13.7) f | 20.7 (6.4, 87.3) | <0.0001 * |
| Dimer (μg/dL) | 7.6 (3.9, 19.1) d,e | 3.8 (1.3, 9.5) f | 12.9 (4.7, 50.8) | <0.0001 * |
| PT (%) | 82.0 ± 25.9 g,h | 92.0 ± 24.1 i | 77.3 ± 29.6 | <0.0001 * |
| APTT (s) | 32.9 ± 15.3 g,h | 30.6 ± 11.5 i | 41.2 ± 27.3 | <0.0001 * |
| Fibrinogen (mg/dL) | 602.6 ± 267.2 g,h | 488.8 ± 217.2 i | 449.2 ± 219.3 | <0.0001 * |
| Antithrombin activity (%) | 79.7 ± 24.4 g,h | 90.1 ± 26.1 i | 73.7 ± 25.2 | <0.0001 * |
* p-value less than 0.05 as significant. (a) PIICS group is significantly different with non-PIICS group by Bonferroni test (p < 0.05/3); (b) PIICS group is significantly different with early death group by Bonferroni test (p < 0.05/3); (c) non-PIICS group is significantly different with early death group by Bonferroni test (p < 0.05/3).; (d) PIICS group is significantly different with non-PIICS group by Steel–Dwass test (p < 0.05); (e) PIICS group is significantly different with early death group by Steel–Dwass test (p < 0.05); (f) non-PIICS group is significantly different with early death group by Steel–Dwass test (p < 0.05); (g) PIICS group is significantly different with non-PIICS group by Tukey–Kramer test (p < 0.05); (h) PIICS group is significantly different with early death group by Tukey–Kramer test (p < 0.05); (i) non-PIICS group is significantly different with early death group by Tukey–Kramer test (p < 0.05). p-values are those of results obtained from one-way analysis of variance. PIICS—persistent inflammation—immunosuppression and catabolism syndrome; ISTH overt DIC—International Society on Thrombosis and Haemostasis—overt disseminated intravascular coagulation; JAAM DIC—Japanese Association for Acute Medicine—disseminated intravascular coagulation; FDP—fibrin/fibrinogen degradation products; PT—prothrombin time; APTT—activated partial thromboplastin time.