Table 5.

Univariate/multivariate logistic regression analysis of persistent inflammation, immunosuppression and catabolism syndrome (PIICS).

	Univariate Logistic Regression Analysis		Multivariate Logistic Regression Analysis
PIICS	Odds Ratio (95% CI)	p-Value	Odds Ratio (95% CI)	p-Value
Age	1.02 (1.01–1.03)	<0.0001 *	1.02 (1.01–1.04)	0.0038 *
Male	1.43 (1.17–1.74)	0.0004 *	2.10 (1.37–3.22)	0.0006 *
SOFA	1.23 (1.19–1.28)	<0.0001 *
APACHEII	1.03 (1.02–1.04)	<0.0001 *	1.04 (1.01–1.06)	0.0012 *
Sepsis	3.70 (3.05–4.49)	<0.0001 *	1.60 (1.00–2.55)	0.049 *
C-reactive protein (mg/dL)	1.07 (1.06–1.08)	<0.0001 *	1.02 (0.99–1.04)	0.18
Albumin (g/dl)	0.57 (0.52–0.62)	<0.0001 *	0.60 (0.42–0.85)	0.0037 *
Lymphocyte counts (×1000/μL) #	0.93 (0.83–1.03)	0.15	1.19 (1.04–1.36)	0.011 *
Hemoglobin (g/dL)	0.95 (0.93–0.98)	0.0015 *	1.09 (1.00–1.19)	0.040 *
Creatinine (mg/dL)	1.11 (1.07–1.15)	<0.0001 *	1.11 (1.01–1.21)	0.034 *
HbA1c (%)	1.07 (0.99–1.14)	0.071	1.14 (1.01–1.31)	0.028 *
ISTH overt DIC	2.46 (1.96–3.08)	<0.0001 *	1.58 (1.02–2.46)	0.042 *
JAAM DIC	2.89 (2.35–3.56)	<0.0001 *
Antithrombin activity (%)	0.98 (0.98–0.99)	<0.0001 *	0.99 (0.99–1.01)	0.81

*; p-value less than 0.05 as significant. (#) unit is changed from usual one based on the clinical insights. SOFA and JAAM DIC were excluded from the multivariable model because these variables had collinearity with APACHE and ISTH overt DIC, respectively. PIICS—persistent inflammation—immunosuppression and catabolism syndrome; ISTH overt DIC— oInternational Society on Thrombosis and Haemostasis—overt disseminated intravascular coagulation; JAAM DIC—Japanese Association for Acute Medicine—disseminated intravascular coagulation; SOFA—sequential organ failure assessment; APACHE—acute physiology and chronic health evaluation.